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AutoCRAT poster wins award at XI Meeting Stem Cell Research Italy

An award-winning poster titled: ‘Long-term serial passage and differentiation capacity of human induced pluripotent stem cell-derived mesenchymal stem cells’ by authors Cansu Gorgun, Elisabetta Palama, Chiara Gentili of UNIGE, and Georgina Shaw and Mary Murphy of NUI Galway was presented by Dr Cansu Gorgun at the XI Meeting Stem Cell Research Italy.

The meeting took place on June 8th-10th, 2022 in Genova, Italy. Congratulations on the prize for the ‘Best Poster’!

AutoCRAT poster wins award at XI Meeting Stem Cell Research Italy2022-07-11T07:07:03+00:00

‘Stamceller kan bli behandling för vanlig ledsjukdom’

Prof. Anders Lindahl, Foto: Elin Lindström

On May 20th, 2022, the University of Gothenburg School of Medicine published an online feature story, Stem cells can be a treatment for common joint disease, showcasing their role and research within the AutoCRAT project. In it, readers will find a lay summary of the work of AutoCRAT scientists, Dr Kristina Vukusic and Dr Josefin Ekholm and Prof. Anders Lindahl.

Read the story in Swedish (English translation available) here: https://www.gu.se/forskning/stamceller-kan-bli-behandling-for-vanlig-ledsjukdom

‘Stamceller kan bli behandling för vanlig ledsjukdom’2022-06-07T12:14:13+00:00

Please meet Prof. Dr Anders Lindahl, University of Gothenburg

In cell culture, Dr Kristina Vukusic and Prof Dr Anders Lindahl, U of Gothenburg.

Prof. Dr Anders Lindahl, PI at the University of Gothenburg (UGOT) kindly answered a set of questions posed by Danielle Nicholson, Pintail Limited in advance of our upcoming meeting in Sweden. Special thanks to Dr Kristina Vukusic, UGOT who helped facilitate this.

How and when did you first become interested in cell biology?

My interest in cell biology started early in my MD studies. Subsequently, I became interested in longitudinal growth and the growth plate during my PhD studies and my experimental work was focused on chondrocyte cell cultures. I was inspired by the clinical use of cell therapy during my postdoc stay at Harvard in the mid-1980s at the Department of the late Professor Howard Green who developed skin cell culture for burn treatment.

 

What is it about chemistry that interests you most these days?

Since I have clinical training in Clinical Chemistry my interest is mainly in the early diagnostics of diseases and with a special interest in the identification of predictive biomarkers for osteoarthritis.

 

What do you see as the biggest challenge to the cell therapy and cartilage repair field right now?

The biggest challenge is to implement the new technology in clinical settings and to do well-performed clinical studies to get these new cell-based therapies registered on the market in the future. The regulatory environment for small companies and academic researchers as well as the reimbursement systems for cell therapies is however challenging.

 

Please describe your group and facilities.

The group now consists of 6 researchers and 2 PhD students. We collaborate The research facility is in the Department of Laboratory Medicine at Sahlgrenska University Hospital, and we have excellent facilities for molecular and cellular research in the Clinical Chemistry laboratory where the group is situated.

 

Your work seems incredibly varied: supervising PhD students, grant writing and admin, lab work, and travel. Which aspects do you enjoy most?

I enjoy most the scientific discussions and testing new ideas and hypotheses. It is always energizing to see the curiosity in young students’ eyes and get all these questions. They get you to feel older but wise too sometimes.

 

For how long have you been in Gothenburg at the university?

I have been a professor since the year 2000 and I have been working as a laboratory director for 10 years. The research facilities are excellent and the collaboration with colleagues at the Sahlgrenska Academy is both easy and rewarding. During the years the network of collaborations has grown big. The tight work of clinicians with researchers and implementation of cross-scientific new technologies such as 3D printing opens up for future personalized medicine.

 

Talk us through your group’s role in AutoCRAT, please.

Our role in the project is to establish a protocol for the derivation of chondrocyte progenitors from induced pluripotent stem cells, to produce cells and secreted vesicles for future regenerative treatment for patients with cartilage defects. Furthermore, we provide adult chondrocytes for comparison and their extracellular vesicles. Since we have over 30 years of experience in Autologous Chondrocyte transplantation we can help with GMP knowledge for cell therapy production. We will also conduct large animal studies here in Gothenburg in the last year of the project, testing the efficacy of our derived cells and their secreted vesicles.

 

What do you find most exciting about the AutoCRAT project?

The project is an international collaborative project between several institutions in Europe and the International work collaboration is very interesting and adds new technologies to the cell biology field. Among other things a robotic production system with advanced monitoring of cell cultures. We are very curious about the outcome of the final product and the therapeutic potential of secreted vesicles from different cell types.

 

Had you worked with Professor Mary Murphy or any of the partners before AutoCRAT?

I have known the group of Mary Murphy and other researchers in AutoCRAT for several years, but we have not had the chance to project collaborations together before. Mary is a great leader and the UGOT team is appreciating the open and familiar atmosphere in the AutoCRAT. We are happy to host the meeting and to welcome all dear collogues to our beautiful Gothenburg.

 

What do you like to do in your free time?

Walking in nature year-round, even in the sometimes tough Swedish weather. Skiing in the winter, mostly in Norway, and boating here on the Swedish West Coast in the summer. I live by the seaside and can´t think of living elsewhere.  I love dogs and have had dogs for over 50 years although not now but I am taking care of my daughter’s dog when needed.

Please meet Prof. Dr Anders Lindahl, University of Gothenburg2022-05-31T10:48:09+00:00

Prof. Dr Bernd Giebel presents at Circulating Biomarkers Europe meeting, Rotterdam

On March 1st and 2nd 2022, Professor Dr Bernd Giebel of the University Medicine Essen presented current research in a talk titled “Clinical Potential of MSC-EVs and Translational Challenges” at the Circulating Biomarkers, Exosomes and Liquid Biopsy Europe meeting held in Rotterdam. In his talk, Prof. Giebel acknowledged his role in the AutoCRAT project.

Prof. Dr Bernd Giebel presents at Circulating Biomarkers Europe meeting, Rotterdam2022-05-23T12:36:49+00:00

Science for Ukraine and Horizon for Ukraine portals open for displaced researchers

Two new portals have recently been launched to present research opportunities for scientists from Ukraine. The first is ‘Science for Ukraine’ which includes a world map and a count of jobs for researchers from Ukraine, https://scienceforukraine.eu/.  Secondly, Ukraine researchers can access the ‘Horizon for Ukraine’ database of positions for researchers, https://ec.europa.eu/info/funding-tenders/opportunities/portal/screen/opportunities/ua-opportunities. Displaced researchers or other specialists from Ukraine can search here for opportunities to become involved in ongoing EU-funded research & innovation projects. Our partner institutions and partnering countries have posted vacancies there. For example, see the screenshot below for positions in Ireland. These opportunities are announced by beneficiaries in such projects. Here, a ‘Contact’ button can be used to indicate interest in a specific opportunity.

Science for Ukraine and Horizon for Ukraine portals open for displaced researchers2022-05-18T08:43:05+00:00

An osteochondral study in the lab at the University of Gothenburg

A team of researchers at the University of Gothenburg, Kristina Vukusic, Josefine Ekholm and orthopaedic surgeon Sebastian Concaro, recently performed an osteochondral study to test whether chondrocytes differentiated from iPS cells can repair cartilage. Kristina kindly provided a short description and photographs of their process.

  1. Osteochondral plugs are cut out of human cartilage harvested from surgical waste at Sahlgrenska University Hospital.
  2. A wound is created in each plug
  3. Cells are injected into the wound: iCHO (IPS cells differentiated into chondrocytes) and control cells  (human chondrocytes from patients)
  4. The wound and cells are sealed with fibrin glue to keep the cells in place.
  5. Plugs incubated

 

An osteochondral study in the lab at the University of Gothenburg2022-04-27T11:15:40+00:00

AutoCRAT partners at LUMC have been awarded funding for two AutoCRAT-related research projects

Springing from their work in AutoCRAT, The Leiden University Medical Center is involved in two new, related NWA-ORC funded projects. The 2022 NWA-ORC science-encompassing funding round is aimed at making interdisciplinary research and innovation possible, so that scientific and societal breakthroughs come within reach.

LUMC is a partner in the LS-NeoCarE consortium that aims to develop regenerative treatment methods for osteoarthritis. LS-NeoCarE wants to improve the lives of people with osteoarthritis by developing durable regenerative cartilage implants. These living implants are based on revolutionary stem cell, bioreactor, and 3D-printing technologies. Through the active involvement of researchers, industry, doctors, and patient organizations, the project creates support among both patients and doctors for applicability and with industry for marketing the developed implants. The project is funded by an NWA-ORC grant of 3.2 million Euros.

Secondly, the LUMC is a partner in the LoaD project that seeks answers to the question: What is ‘healthy load’ for people with osteoarthritis?” This research focuses on investigating what a healthy exercise load is for osteoarthritis patients so that they can receive tailor-made support. This project is also funded by an NWA-ORC grant.

AutoCRAT partners at LUMC have been awarded funding for two AutoCRAT-related research projects2022-05-03T10:16:19+00:00

LUMC showcases AutoCRAT and osteoarthritis research at OARSI 2022 meeting in Berlin

At the (Osteoarthritis Research Society International) OARSI 2022 World Congress in Berlin, Professor Ingrid Meulenbelt of the LUMC  was the invited keynote speaker. Her talk was titled Mechanobiology and OA: Elucidating Mechano-Pathology of Osteoarthritis. The meeting was held from April 7th to April 10th.

Also, while there, Niek Bloks presented COL6A3 mutation causing aberrant collagen VI function has interacting effect with mechanical loading. This body of work is the result of a close collaboration (NIH project) with Farshid Guilak and Zainab Harissa from Washington University in St. Louis, USA. Marcella van Hoolwerff presented work entitled Identification and functional characterization imbalanced OA associated fibronectin1 splice variants. Congratulations to Niek and Marcella who were awarded for their highest-rated abstracts at OARSI 2022 in Berlin. See the photo below.

In addition, LUMC’s Nicoline Korthagen, Ilja Boone, and Yolande F.M. Ramos presented a poster entitled Towards application of cell therapy using hiPSC-derived MSCs as a stable ‘off-the-shelf’ cell source acknowledging AutoCRAT’s Horizon 2020 funding.

Well done to all!

LUMC showcases AutoCRAT and osteoarthritis research at OARSI 2022 meeting in Berlin2022-04-14T16:40:03+00:00

AutoCRAT presented by Fraunhofer IPT at Stem Cell Network NRW 2022 meeting

Ferdinand Biermann

Ferdinand Biermann

The Stem Cell Network NRW 13th internal Meeting will take place on May 6th and 7th this year at the Akademie-Mont-Cenis in Herne. At the meeting, Fraunhofer IPT’s Ferdinand Biermann will present the AutoCRAT Project concept. His talk on Saturday, May 7th, at 9:30 am (German time) is entitled: Fully automated production of mesenchymal stem cells, chondrocytes and extracellular vesicles for osteoarthritis treatment. 

This 2022 meeting aims to showcase the breadth of stem cell research taking place in North Rhine-Westphalia, stimulate exchange among researchers and, above all, will integrate research groups that recently joined the Network.

The Stem Cell Network North Rhine-Westphalia has existed since 2002 and is comprised not only of biomedical institutes and clinics but also ethical, legal, and social science institutions. This composition reflects the transdisciplinary approach of the network: In addition to promoting biomedical stem cell research in North Rhine-Westphalia (NRW), ethical, legal, and social science studies are intended to ensure a responsible approach to the topic, especially in view of the high expectations placed on this research area in the future. A total of almost 80 institutions in NRW form the network, at 23 different institutions.

AutoCRAT presented by Fraunhofer IPT at Stem Cell Network NRW 2022 meeting2022-05-03T08:05:43+00:00

Prof. Dr Giebel presents EV research in Rotterdam

University Medicine Essen‘s Prof. Dr Bernd Giebel facilitated a talk entitled ‘Clinical Potential of MSC-EVs and Translational Challenges’ at the SelectBIO meeting in Rotterdam. This exposition, Circulating Biomarkers, Exosomes and Liquid Biopsy Europe 2022 was held March 1st and 2nd. The annual conference brought together academics and industry participants from around the world focused on research, biomarker analyses and therapeutics development leveraging the cargo from Exosomes and Extracellular Vesicles (EVs).
An important component of this conference was to focus upon the development of Liquid Biopsies utilizing circulating cell-free DNA (cfDNA), circulating tumour cells (CTCs) and other biomarkers found in biofluids.

Prof. Dr Giebel presents EV research in Rotterdam2022-03-07T15:05:38+00:00

Welcome to the AutoCRAT team, Iris Boot, Panaxea

Iris Boot

We extend a warm welcome to the AutoCRAT Project, Iris Boot!

Iris recently started as a researcher at Panaxea B.V.  She studied Psychology at the University of Leiden. During this time, she developed an interest in the research field of health sciences, which led to the Research Master in Health Sciences at Maastricht University. As part of the master’s degree, she did an internship at the Nutrition Biomed Research Institute in Australia.

After her studies, Iris started working as a Data Analyst at a transport company. Here, she further developed her analytical skills and gained experience in project management, but she missed the connection with healthcare. This made Panaxea a logical next step in her career. As a junior HTA researcher/consultant at Panaxea, she can apply the knowledge gained from her master’s and contribute to informed decision-making in healthcare. In addition to her work at Panaxea, Iris is a PhD candidate at Maastricht University. Her research focuses on the relationship between diet and the risk of developing bladder cancer.

Welcome to the AutoCRAT team, Iris Boot, Panaxea2022-02-24T09:29:26+00:00

LUMC present AutoCRAT research at Orthopedic Research Society meeting in Tampa, Florida, USA

A poster depicting the AutoCRAT research of our partners at the Leiden University Medical Center was presented by Dr Yolande F. M. Ramos at the Orthopedic Research Society 2022 annual meeting in Tampa, Florida, USA. The poster of work was entitled  “Towards application of cell therapy using hiPSC-derived MSCs as stable ‘off-the-shelf’ cell source” and was selected among late-breaking abstracts for presentation. The meeting was held February 4th- 8th.

For over 65 years, the Orthopaedic Research Society has been the leading international research society dedicated to accelerating musculoskeletal discovery to improve health. The ORS community is multi-disciplinary and is comprised of members from academia, industry/private sector, government, and private practice at all career levels from around the world.

 

LUMC present AutoCRAT research at Orthopedic Research Society meeting in Tampa, Florida, USA2022-02-10T13:29:21+00:00

Publication news! AutoCTRAT research by UGOT published in Cell Regeneration

Congratulations to researchers and authors at the University of Gothenburg and Cline Scientific, H. Evenbratt, L. Andreasson, V. Bicknell, M. Brittberg, R. Mobini and S. Simonsson. Their study entitled: Insights into the present and future of cartilage regeneration and joint repair appears in the journal Cell Regeneration, (Cell Regen 11, 3 (2022). https://doi.org/10.1186/s13619-021-00104-5) today, February 2nd, 2022.

Download the open-access PDF here.

Publication news! AutoCTRAT research by UGOT published in Cell Regeneration2022-02-02T15:34:42+00:00

New AutoCRAT publication from AutoCRAT team at the Universita di Genova

Congratulations to the AutoCRAT research team at the Universita di Genova for their recent publication in STEM CELLS Translational Medicine. Cansu Gorgun, Maria Elisabetta Palamà, Daniele Reverberi, Maria Cristina Gagliani, Katia Cortese, Roberta Tasso, and Chiara Gentili published “Role of from adipose tissue- and bone marrow-mesenchymal stromal cells in endothelial proliferation and chondrogenesis” in STEM CELLS Translational Medicine.

In addition, their image was chosen for the December 2021 issue, Volume 10, Issue 12. Well done!

The DOI for this paper is https://doi.org/10.1002/sctm.21-0107  You can download the PDF of the open-access paper here.

New AutoCRAT publication from AutoCRAT team at the Universita di Genova2021-12-09T16:13:17+00:00

AutoCRAT consortium assembles for plenary meeting in Aachen, DE

The AutoCRAT team came together on 25 and 26 November 2021 for a “hybrid” plenary meeting.

In-person attendees were hosted in Aachen, Germany by Fraunhofer IPT. Other members of the team joined online. The meeting was held as we received confirmation of approval of our Month 18 report. Partners had an opportunity to update the consortium on recent results and discuss plans for the next phase of the programme. The in-person attendees also enjoyed a tour of the platforms and facilities on-site in Aachen, which was of particular benefit for the partners transferring AutoCRAT processes into automation.

Many thanks to the team at Fraunhofer IPT for hosting the meeting.

AutoCRAT consortium assembles for plenary meeting in Aachen, DE2021-11-29T16:54:23+00:00

Meet the Women in AutoCRAT: Two Postdoctoral Researchers at UNIGE

Dr Elisabetta Palamà, UNIGE

Dr Cansu Gorgun, UNIGE

Danielle Nicholson, Pintail Limited pitched some questions to the postdocs at the University of Genova Drs Elisabetta Palamà and Cansu Gorgun to continue our series of interviews with women researchers in AutoCRAT.

Danielle: Thank you both for agreeing to communicate in this way and share your thoughts. This is very helpful to give everyone a better idea about how you work and the University of Genova’s work within AutoCRAT.

Danielle: Is osteoarthritis (OA) very prevalent in Italy?

Elisabetta: In Italy, rheumatic diseases affect 5,500,000 people, which is about 10% of the total population. OA is by far the most common disease among rheumatic patients (72.6% of rheumatic diseases).  Considering that Italy has a ‘greater than 65-years-old’ population percentage among the highest in Europe (22.8%), OA is becoming an issue affecting a large part of the population. (1)

Cansu: From the country point of view, the OA burden in Italy is mostly psychical and psychological. Especially the difficulties in maintaining their activities of daily living among OA patients dramatically affects the quality of life. (2)

 Danielle: How did you get interested in regenerative medicine and cell biology?

Cansu: When I was writing my bachelor thesis, I found a paper about tissue engineering and regenerative medicine and just realized that I had not known anything about cell culture. So, I decided to do my master’s degree in the Stem Cell Biology Department, and suddenly I entered the ‘Regenerative Medicine’ world. But I can say that even though I completed my PhD in Regenerative Medicine and Tissue Engineering, and I am a postdoctoral fellow in this field, still the multidisciplinary challenges in the regenerative field are quite fascinating for me, every day is a new adventure and there is always a lot to learn!

Elisabetta: Like many scientists, I have been interested in science since I was a child. I was interested in how the world works and this pushed me to undertake a scientific career. In my master’s thesis, I followed a project on the regeneration of myelin and Schwann cells. This regenerative medicine field really fascinated me, so later I looked for a PhD in Regenerative Medicine and Tissue Engineering to improve my knowledge.

Danielle:  Tell us a bit about the AutoCRAT research team at the University of Genoa (UNIGE). What are your roles within it? Where are you situated?

Cansu: Our AutoCRAT research team is situated within the Department of Experimental Medicine (DIMES), UNIGE.  To the AutoCRAT project, Prof. Chiara Gentili’s research team at the Department of Experimental Medicine (DIMES, https://dimes.unige.it/) at the University of Genoa brings many years of experience and expertise in cell production and animal models of regenerative medicine, including the production of and optimisation of mesenchymal stem cells and extracellular vesicles (EVs). Elisabetta and I are on Prof. Gentili’s team which currently consists of two post-doctoral researchers, one PhD student, one Master student and two Bachelor students. Our laboratory is inside a public hospital (Ospedale Policlinico San Martino) and we also have access to the research facilities of the hospital. Our research is focused on the EVs in cartilage biology and their biological function in OA treatment. 

Elisabetta: I have a common research interest with Cansu. So, we work together on our experiments such as EV  isolation, characterization and biological validation. Recently, we started to explore the world of proteomics, in collaboration with the proteomic facility of Policlinico San Martino.

Danielle: Do you have connections within the hospital? If so, do you have any interactions with any OA patient groups?

Cansu: Even though our laboratory is located inside the public hospital in Genova, unfortunately, we have never had contact with OA patients directly. Via clinicians, we collect patients’ cartilage samples resulting from knee replacement surgeries. 

Elisabetta: We normally go into surgery rooms only to take samples, never interacting with the patients. It would be interesting and exciting to be a part of a clinical trial team and have the chance to enter this field.

Danielle: What is your favourite aspect of your work?

Cansu: For me, the best is to do experiments. The preparation, planning and waiting to see and analyze the results are the favourite aspects for me. Sometimes the results can be not so promising but that’s why it is called an experiment. 

Elisabetta: I think I like every single aspect of this work, even failure. There is no growth without failure! Then of course I love to plan and carry out experiments, I like writing and reading to learn more from other groups. I also like to supervise students, especially when after so much effort and teaching, they become good, independent and interested young researchers.

 Danielle: What is the most exciting aspect of AutoCRAT?

Cansu: I think it is the diversity. We have different research groups, from different backgrounds and from different countries and cultures. Most importantly the diverse, interdisciplinary aspect of AutoCRAT drives the success of the project. 

Elisabetta: I totally agree with Cansu. It is always nice to create a link with different groups and combine different minds for a common aim. AutoCRAT will also have a great impact on healthcare and on science, developing new technologies and therapies.

 Danielle: What do you like to do in your free time in and around Genova?

Cansu: I moved to Genoa from Turkey around four years ago and from that moment, I spent all my free time discovering food in Genoa. And honestly, I can say that I can still find new food around the city :) And of course, the time left over from the amazing Italian food is spent on discovering the Ligurian coast and hills. 

Elisabetta: I moved to Genova in 2015, leaving my family in the South of Italy. Now I live with my boyfriend and our cute dachshund, Kimi :) So I normally spend my free time going for long and nice walks in and around Genova.

(1) https://ec.europa.eu/eurostat/statistics-explained/index.php?title=Archive:Struttura_e_invecchiamento_della_popolazione#:~:text=Per%20quanto%20riguarda%20il%20numero,4%20%25)%20quelle%20pi%C3%B9%20basse.​​

(2) https://www.statista.com/statistics/785104/elderly-population-in-italy/

Meet the Women in AutoCRAT: Two Postdoctoral Researchers at UNIGE2021-10-29T08:07:09+00:00

Prof. Dr Giebel presents AutoCRAT research at September meetings in France and Italy

Prof Dr Bernd Giebel, University Medicine Essen

The Extracellular Vesicles Thematic Summer School 2021 was held in Le Grande Motte, France this year. The three-day training school focused on technological and translational themes related to therapy and diagnosis and assembled world-class international scientists from academia, industry and clinicians. On September 14th, the second day, Prof Dr Bernd Giebel delivered his talk: Clinical potential of MSC-EVs and translational challenges. Read the entire programme of the summer school here. In total, fifty delegates attended the summer school.

On Thursday, September 21st, 2021, Prof. Dr Bernd Giebel was an invited speaker at the EV-Ita Symposium. His talk was titled: Mesenchymal Stem Cell-derived Extracellular Vesicles: a Potential New Tool in Regenerative Medicine. This two-day meeting took place in Ciocco, Italy. Approximately 150 researchers attended this talk.

 

 

 

 

Prof. Dr Giebel presents AutoCRAT research at September meetings in France and Italy2021-09-27T15:03:49+00:00

AutoCRAT research presented by Prof. Dr Giebel and Dr Elisabetta Palamà at Stem Net Conference in Padua

The StemNet conference took place in the MUSME, the Museum of History of Medicine in Padua, Italy from the 22nd to the 24th of September 2021. During the ‘Cell-free Therapy’ session on September 24th, Prof. Dr Bernd Giebel of the University Hospital Essen facilitated a talk entitled: Functional heterogeneity of cellular and extracellular vesicle-based therapeutics: implications for the development of potency assays. Dr Elisabetta Palamà of UNIGE presented at the international conference, as well. Her talk was titled “Clinical grade mesenchymal stromal cells-derived extracellular vesicles promote human cartilage recovery in vitro.”

The meeting was co-sponsored by the Gruppo di Italiani Staminali Mesenchimali, GISM.

 

 

AutoCRAT research presented by Prof. Dr Giebel and Dr Elisabetta Palamà at Stem Net Conference in Padua2021-10-07T09:31:29+00:00

UNIGE’s Researchers present AutoCRAT findings at EV-Ita Symposium in Lucca

Prof. Chiara Gentili and Dr Elisabetta Palama of the University of Genova attended and presented posters at the EV-Ita Symposium. The meeting took place from September 20th to the 22nd in Lucca, Italy. Prof. Gentili’s poster was entitled: Extracellular vesicles derived from mesenchymal stromal cells cultured in a clinical-grade medium promote human cartilage recovery. Dr Palama’s poster title was “Role of Extracellular Vesicles from adipose tissue- and bone marrow mesenchymal stromal cells in endothelial proliferation and chondrogenesis”.

Dr Elisabetta Palamà

 

UNIGE’s Researchers present AutoCRAT findings at EV-Ita Symposium in Lucca2021-10-07T09:39:28+00:00
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